ABSTRACT
Objective: The purpose of this study is; firstly, to find out the prevalence of drug resistant Acinetobacter baumannii, secondly, to find the most common site of infection by Acinetobacter baumannii, and thirdly, to assess the in vitro effectiveness of tigecycline against drug resistant Acinetobacter baumannii, in our hospital setting
Study Design: Retrospective/Observational study
Setting: Charsada Teaching Hospital affiliated with Jinnah Medical College Peshawar
Period: One year from January 2016 to December 2016
Methodology: All the reports occurring during this study period with positive diagnosis for Acinetobacter were retrieved from the archives, irrespective of patient's age and gender. Only one isolate of Acinetobacter per patient was considered in the study. The organisms were identified and species determined manually. Susceptibility for antimicrobial agents was determined according to criteria of CLSI 2016. MIC for tigecycline in the isolates was determined by E-test
Results: On analyzing all the Acinetobacter isolates [n=391] during one year time, it was found that the large majority of these isolates were of Acinetobacter baumannii [96.2%], while only few were of Acinetobacter lwoffii [3.8%]. Multidrug resistant Acinetobacter baumannii represented about one third [31%] of all the Acinetobacter baumannii isolates. Most of the isolates of Acinetobacter baumannii were from skin and soft tissue wounds [44.4%], followed by isolates from respiratory secretions [42.7%], urine [6.8%], blood [5.2%] and CSF [0.9%] [Table II]. The isolates of Acinetobacter baumannii showed maximum sensitivity to Tigecycline [88.9%], followed by Colistin [81.2%] and Polymyxin [79.5%] [Table III]
Conclusions: Drug resistant Acinetobacter baumannii is present in 31% of isolates, it is most commonly isolated from infected wounds and respiratory tract secretions in debilitated patients, and also Tigecycline is an excellent treatment choice for infections caused by drug resistant Acinetobacter baumannii
ABSTRACT
Objective: The purpose of this study is, firstly, to find the pattern of ear diseases in the community, as no such pattern study is currently available. Secondly, to impart awareness regarding microscopic appearances of the common ear diseases encountered in this pattern study
Study Design: Observational / descriptive study
Place and Duration of Study: This study was conducted at the Surgical Pathology archives of the Laboratory of Charsada Teaching Hospital affiliated with Jinnah Medical College Peshawar from 2010 to 2015
Materials and Methods: In this study, all the cases of ear diseases from surgical pathology archives of the laboratory of Charsada Teaching Hospital were retrieved. All the slides and the diagnoses for the retrieved cases were reviewed by the histopathologist and the final diagnoses were recorded; the disease pattern was determined, keeping in view the number of cases for each diagnostic category and the patient's age
Results: The review of these cases between 2010 and 2015 showed that most of the biopsy specimens were from external ear while few were from the middle ear. The first five commonest conditions constituted almost two thirds of the total number of cases. The congenital anomalies and juvenile xanthogranulomas were most common in the first decade of life. Benign and malignant tumors were uncommon and seen mostly after the third decade of life
Conclusions: Congenital anomalies and inflammation associated diseases are common in the first three decades of life, whereas benign and malignant neoplasms are more common after the third decade of life
ABSTRACT
We present a case of follicular dendritic cell sarcoma in a 48 years old Saudi female who reported with slowly progressive right sided extranodal neck mass associated with pulmonary metastasis. Clinical examination, histopathologic features including distinct immunostains combine together to make the rare diagnosis of follicular dendritic cell sarcoma. This entity is often misdiagnosed due to non-consideration in differential diagnosis of sarcoma. It carries a significant potential for regional as well as distant spread and hence categorized as intermediate risk malignancy. Clinical, histopathological and immunohistochemical aspects and therapeutic options of this unusual case are discussed
ABSTRACT
80 patients of chronic liver disease with 10 healthy controls were studied in the Microbiology Department, Basic Sciences Medical Institute, Jinnah Postgraduate Medical Center [BMSI, JPMC], Karachi. All patients were suffering from chronic liver disease i.e. chronic persistent hepatitis, chronic active hepatitis, cirrhosis of liver and hepatocellular carcinoma for more than six months duration. The alanine aminotransferase [ALT] was persistent / fluctuating raised [>40 IU/L for males and > 35 IU/L for females] for more than three months. Samples were collected from admitted patients of various hospitals of Karachi. Ten healthy individuals with normal ALT were also included in the study. The prevalence among chronic liver disease was found to be 40%. The prevalence with history of blood transfusion, parentral therapies, hemodialysis and with no known history of possible contact with the virus was found 45%, 45.6%, 100% and 28.7% respectively
Subject(s)
Humans , Male , Female , Hepatitis C Antibodies/analysis , Hepatitis C/transmission , Alanine Transaminase/analysis , Chronic Disease , Chronic DiseaseABSTRACT
A study of 52 patients with chronic liver disease due to hepatitis C virus [HCV] following blood transfusion and parenteral therapies was conducted at the Department of Microbiology. Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre. Karachi. The patients were suffering from chronic liver disease i.e. chronic hepatitis, cirrhosis of liver and hepatocellular carcinoma for more than six months with history of blood transfusion and parenteral injections [with non-disposable syringe] for therapeutic reasons at least for three months prior to the development of the symptoms of liver disease. All these patients had persistant/fluctuating raised level of alanine aminotransferase for more than 3 months. The mean ALT was 65.1 IU/L with a range of 43-165 IU/L. The prevalence of anti-HCV was found to be 47.6% among post-transfusion cases and 45.16% in multiple parenteral therapy cases. Ten samples from healthy individuals were also included in the study, their mean ALT was 18.9 IU/L with a range of 12.1 to 30.01 IU/L. No case was found positive for anti-HCV in ten control cases